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“灭活益生菌”儿童营养干预的研究

“灭活益生菌”儿童营养干预的研究
  • 灭活益生菌”是将有益菌通过灭活技术,使其不再具有生命力,但仍对人体起到有益健康作用而制成的益生菌 。 与传统益生菌相比,灭活益生菌表现出了许多优点,如明确的作用机制、已知的分子结构、靶细胞下游途径中更容易获得细胞受体、易于生产、储存和更好地用于工业化水平的生产等,都决定了其具有重大的研究和利用价值。


  • 益生菌的使用与各种健康益处有关,但是其可能还会过度刺激免疫系统、引发全身感染等问题,且儿童脆弱的免疫系统可能会增加益生菌的不良反应;

  • 基于此,学者们开发了“灭活益生菌”,其存在于细胞表面的细胞壁多糖、肽聚糖、表面蛋白和磷壁酸参与灭活益生菌与宿主的作用,提供健康益处;

  • 目前证据表明灭活益生菌具备抗黏附、抗生物膜、抗高血压、抗炎、抗氧化和抗病原体等作用;

  • 并且在儿童使用中也增强了安全性。



Recent advances in the concept of paraprobiotics: Nutraceutical/functional properties for promoting children health

“灭活益生菌”概念的最新进展:促进儿童健康的营养/功能特性

10.1080/10408398.2021.1996327

2021-11-08, Article


Probiotics consumption has been associated with various health promoting benefits, including disease prevention and even treatment by modulating gut microbiota. Contrary to this, probiotics may also overstimulate the immune system, trigger systemic infections, harmful metabolic activities, and promote gene transfer. In children, the fragile immune system and impaired intestinal barrier may boost the occurrence of adverse effects following probiotics’ consumption. To overcome these health challenges, the key focus has been shifted toward non-viable probiotics, also called paraprobiotics. Cell wall polysaccharides, peptidoglycans, surface proteins and teichoic acid present on cell’s surface are involved in the interaction of paraprobiotics with the host, ultimately providing health benefits. Among other benefits, paraprobiotics possess the ability to regulate innate and adaptive immunity, exert anti-adhesion, anti-biofilm, anti-hypertensive, anti-inflammatory, antioxidant, anti-proliferative, and antagonistic effects against pathogens, while also enhance clinical impact and general safety when administered in children in comparison to probiotics. Clinical evidence have underlined the paraprobiotics impact in children and young infants against atopic dermatitis, respiratory and gastrointestinal infections, in addition to be useful for immunocompromised individuals. Therefore, this review focuses on probiotics-related issues in children’s health and also discusses the Lactobacillus and Bifidobacterium spp. qualities for qualifying as paraprobiotics and their role in promoting the children’s health.

First Authors:
Harsh Kumar,Francine Schütz

Correspondence Authors:
Dinesh Kumar,Kamil Kuča,Natália Cruz-Martins

All Authors:
Harsh Kumar,Francine Schütz,Kanchan Bhardwaj,Ruchi Sharma,Eugenie Nepovimova,Daljeet Singh Dhanjal,Rachna Verma,Dinesh Kumar,Kamil Kuča,Natália Cruz-Martins



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